Protein-DNA complex disassembly

Across TCGA patient cohorts, RNA activity of the Protein-DNA complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKB, TOP2A, and KIFC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-DNA complex disassembly activity versus AURKB in LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AURKB →	+0.962	+0.304	.001	.002	3	8
LUAD	TOP2A →	+1.048	+0.274	.003	.005	3	8
LUAD	KIFC1 →	+0.949	+0.323	.001	.001	3	8
LUAD	NUF2 →	+0.936	+0.359	.001	<.001	3	7
BRCA	DEPDC1 →	+0.973	+0.355	<.001	<.001	3	7
LUAD	PRR11 →	+0.747	+0.301	.003	.003	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032986 vs AURKB — LUAD

Explore this scatter interactively →