Positive regulation of transcription elongation by RNA polymerase II

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription elongation by RNA polymerase II pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM23, AZIN1, and CRLF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription elongation by RNA polymerase II activity versus RBM23 in SOFT_TISSUE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RBM23 →	+1.267	+0.357	.004	.009	3	5
LUNG_NSCLC_LUAD	AZIN1 →	+0.614	+0.494	.006	.004	2	6
SKIN	CRLF2 →	-0.181	-0.332	.007	.002	3	4
UPPER_AERODIGESTIVE_TRACT	IAH1 →	-0.828	-0.334	<.001	.008	3	4
BLOOD_Leukemia	LMNB1 →	+0.831	+0.639	.008	.007	3	4
BREAST	HNRNPD →	+0.535	+0.452	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032968 vs RBM23 — SOFT_TISSUE

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