Transforming growth factor beta1 production

Across TCGA patient cohorts, RNA activity of the Transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL9, CYGB, and MLKL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transforming growth factor beta1 production activity versus MYL9 in GBM (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYL9 →	+1.004	+0.176	<.001	.009	3	5
CCRCC	CYGB →	+0.759	+0.505	<.001	.003	3	4
OV	MLKL →	+0.593	+0.269	<.001	.001	3	4
CCRCC	LINC02408 →	+0.187	+0.395	.002	.004	3	4
GBM	UPP1 →	+1.133	+0.293	<.001	<.001	3	4
GBM	TIMP1 →	+1.535	+0.213	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032905 vs MYL9 — GBM

Explore this scatter interactively →