Transforming growth factor beta1 production

Across TCGA pan-cancer cohorts, RNA activity of the Transforming growth factor beta1 production pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Transforming growth factor beta1 production pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BLCA, show the opposite pattern, with higher activity associated with better survival.

MESO, KIRP, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	III,IV	0.345	0.696	<.001	90	view →
KIRP	OS	Tertile	II,III,IV	0.653	0.940	<.001	77	view →
ACC	OS	Median	All	0.772	0.943	.003	37	view →
LGG	OS	Tertile	All	0.732	0.869	<.001	34	view →
HNSC	DFS	Tertile	III,IV	0.625	0.468	.005	25	view →
THYM	OS	Median	II,III,IV	0.706	1.000	.009	24	view →
LAML	DFS	Quartile	All	0.282	0.630	.016	22	view →
BLCA	OS	Quartile	III,IV	0.733	0.569	.016	22	view →
STAD	DFS	Quartile	II,III,IV	0.450	0.803	.005	20	view →
DLBC	DFS	Median	IV	1.000	0.281	.005	19	view →
UVM	DFS	Median	III,IV	0.184	0.763	<.001	17	view →
ESCA	OS	Median	All	0.563	1.000	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0032905–MESO (OS)

Open the MESO breakdown →