Positive regulation of organic acid transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of organic acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM4, MCM5, and MCM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of organic acid transport activity versus MCM4 in LSCC (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM4 →	-0.637	-0.048	<.001	<.001	3	7
LSCC	MCM5 →	-0.626	-0.050	<.001	<.001	3	7
GBM	MCM2 →	-0.762	-0.075	<.001	<.001	3	7
GBM	EXOSC9 →	-0.302	-0.083	<.001	<.001	3	6
LSCC	MCM6 →	-0.653	-0.052	<.001	<.001	3	6
LSCC	MCM7 →	-0.630	-0.051	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032892 vs MCM4 — LSCC

Explore this scatter interactively →