Positive regulation of organic acid transport

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of organic acid transport pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRP and THCA, show the opposite pattern, with lower activity in tumor tissue.

KIRP, THCA, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	Female	II,III,IV	−0.082	<.001	9	view →
THCA	Female	II,III,IV	−0.030	<.001	7	view →
KICH	Female	All	−0.063	<.001	6	view →
BRCA	All	III,IV	−0.059	<.001	6	view →
UCEC	All	All	−0.035	<.001	6	view →
KIRC	All	III,IV	−0.027	.006	5	view →
LIHC	All	All	−0.020	<.001	5	view →
BLCA	Female	III,IV	+0.025	.009	3	view →
LUSC	All	All	−0.017	.011	3	view →
LUAD	All	IV	−0.080	.029	2	view →
CHOL	All	All	−0.031	.012	2	view →
PRAD	All	All	+0.023	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0032892–KIRP

Open the KIRP breakdown →