Negative regulation of natural killer cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of natural killer cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF40, CCDC142, and CCDC77, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF40 grouped by Negative regulation of natural killer cell activation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNF40 →	-0.334	-1.614	.006	.001	3	4
BLOOD_Leukemia	CCDC142 →	-0.888	-1.140	.003	.004	2	5
BLOOD_Myeloma	CCDC77 →	-0.861	-1.162	.004	.007	3	4
SKIN	ASB3 →	-0.372	-1.076	<.001	<.001	3	4
SKIN	LRPAP1 →	+0.695	+1.327	.009	<.001	2	5
SKIN	ZNF546 →	-0.290	-0.821	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF40 by Negative regulation of natural killer cell activation activity — BONE

Explore this box plot interactively →