Bile acid secretion

Across TCGA patient cohorts, RNA activity of the Bile acid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES1, PODNL1, and CYP27A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bile acid secretion activity versus CES1 in LSCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CES1 →	+1.281	+0.066	<.001	<.001	3	8
PDAC	PODNL1 →	+0.720	+0.049	.005	.003	3	4
COAD	CYP27A1 →	+0.456	+0.051	<.001	<.001	3	4
LSCC	DIAPH2 →	+0.312	+0.058	<.001	<.001	3	4
BRCA	HNRNPC →	-0.284	-0.044	<.001	<.001	3	4
BRCA	KANK2_S323 →	+0.340	+0.038	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032782 vs CES1 — LSCC

Explore this scatter interactively →