Negative regulation of interleukin-2 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-2 production pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIGLEC1, PLEKHO2, and SKAP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-2 production activity versus SIGLEC1 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SIGLEC1 →	+0.591	+0.071	<.001	<.001	3	9
UCEC	PLEKHO2 →	+0.413	+0.050	<.001	<.001	3	8
UCEC	SKAP2 →	+0.599	+0.059	<.001	<.001	3	8
OV	CYRIB →	+0.429	+0.057	<.001	<.001	3	8
GBM	EHBP1L1 →	+0.331	+0.072	<.001	<.001	3	8
GBM	MSN →	+0.544	+0.089	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032703 vs SIGLEC1 — LSCC

Explore this scatter interactively →