Negative regulation of interleukin-2 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-2 production pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMNL1, AP3S1, and GKAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FMNL1 grouped by Negative regulation of interleukin-2 production-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FMNL1 →	-1.429	-0.956	<.001	.003	3	5
LUNG_NSCLC_LUAD	AP3S1 →	-0.698	-0.702	.001	.002	3	5
LIVER	GKAP1 →	-1.293	-1.611	<.001	<.001	3	4
LIVER	TSPAN4 →	-1.773	-1.708	.001	<.001	3	4
LIVER	PER3 →	-1.741	-1.197	.002	.007	3	4
URINARY_TRACT	ABL2 →	-2.526	-2.055	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FMNL1 by Negative regulation of interleukin-2 production activity — PANCREAS

Explore this box plot interactively →