Negative regulation of interleukin-2 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-2 production pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRR, NDRG2, and RALGDS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-2 production activity versus PTPRR in LARGE_INTESTINE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTPRR →	+1.453	+1.319	<.001	<.001	3	5
LUNG_SCLC	NDRG2 →	-2.041	-1.134	.002	.001	3	5
BONE	RALGDS →	-1.547	-1.601	.001	.001	3	4
OESOPHAGUS	MYO10 →	-1.390	-1.281	.003	.002	3	4
OESOPHAGUS	CCT3 →	-0.896	-1.134	.001	.009	3	4
OESOPHAGUS	RFC1 →	-0.779	-1.573	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032703 vs PTPRR — LARGE_INTESTINE

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