Negative regulation of interleukin-1 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-1 production pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOMER3, LACTB, and NR1H2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOMER3 grouped by Negative regulation of interleukin-1 production-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HOMER3 →	-3.281	-1.848	<.001	.003	3	5
LUNG_NSCLC_LUAD	LACTB →	-0.793	-0.681	<.001	<.001	3	5
SOFT_TISSUE	NR1H2 →	-1.176	-1.293	.001	.004	3	5
LIVER	TGFB1I1 →	-4.129	-1.478	.006	.007	2	5
CNS	RNF227 →	+0.697	+1.087	<.001	<.001	3	4
STOMACH	DTX4 →	+1.583	+1.549	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOMER3 by Negative regulation of interleukin-1 production activity — LIVER

Explore this box plot interactively →