Negative regulation of type II interferon production

Across TCGA patient cohorts, RNA activity of the Negative regulation of type II interferon production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, CSF3R, and FCAR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type II interferon production activity versus MEFV in HNSC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MEFV →	+0.831	+0.424	<.001	.008	3	7
LSCC	CSF3R →	+0.970	+0.192	<.001	<.001	3	6
GBM	FCAR →	+0.670	+0.395	<.001	<.001	3	6
GBM	PELATON →	+0.725	+0.364	<.001	<.001	3	6
GBM	SLC11A1 →	+1.131	+0.367	<.001	<.001	3	6
GBM	ADGRE2 →	+0.684	+0.342	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032689 vs MEFV — HNSC

Explore this scatter interactively →