Negative regulation of type II interferon production

Across TCGA cell cohorts, RNA activity of the Negative regulation of type II interferon production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZH2, MRPS5, and STUB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type II interferon production activity versus EZH2 in LUNG_NSCLC_LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EZH2 →	+0.490	+0.163	.002	.007	3	7
LARGE_INTESTINE	MRPS5 →	+0.344	+0.265	.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	STUB1 →	+0.567	+0.206	.002	.002	3	6
UPPER_AERODIGESTIVE_TRACT	MDH2 →	+0.859	+0.228	.001	.003	3	6
LUNG_NSCLC_LUAD	NOM1 →	+0.663	+0.200	.002	.003	3	6
LUNG_NSCLC_LUSC	DDHD1 →	+1.713	+0.481	.009	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032689 vs EZH2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →