Negative regulation of chemokine production

Across TCGA patient cohorts, RNA activity of the Negative regulation of chemokine production pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPM1F, API5_S464, and NCAPG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine production activity versus PPM1F in COAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PPM1F →	+0.204	+0.028	.001	.005	3	8
COAD	API5_S464 →	-0.447	-0.035	.001	.001	3	7
GBM	NCAPG →	-0.578	-0.060	<.001	.002	3	7
COAD	CHD8_S2008 →	-0.604	-0.029	.004	.006	3	7
BRCA	RBM25 →	-0.187	-0.033	<.001	<.001	3	7
HNSC	ARHGAP24_S415 →	+0.573	+0.055	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032682 vs PPM1F — COAD

Explore this scatter interactively →