Negative regulation of chemokine production

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of chemokine production pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 26 member genes.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher Negative regulation of chemokine production pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THYM and SKCM, show the opposite pattern, with higher activity associated with better survival.

PAAD, LGG, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Median	All	0.205	0.487	<.001	52	view →
LGG	DFS	Median	All	0.285	0.500	<.001	48	view →
STAD	DFS	Quartile	II,III,IV	0.280	0.533	.006	44	view →
THYM	DFS	Tertile	III,IV	1.000	0.371	.007	18	view →
SKCM	OS	Median	All	0.489	0.279	.009	17	view →
LIHC	DFS	Quartile	II,III,IV	0.594	0.373	.010	16	view →
UVM	OS	Tertile	All	0.618	0.882	.046	11	view →
COAD	DFS	Quartile	IV	0.678	0.260	.014	10	view →
GBM	OS	Median	All	0.306	0.482	.017	9	view →
ACC	DFS	Tertile	IV	0.136	0.656	.024	9	view →
LUSC	DFS	Tertile	III,IV	0.665	0.410	.029	7	view →
BLCA	OS	Tertile	III,IV	0.479	0.648	.021	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0032682–PAAD (OS)

Open the PAAD breakdown →