Negative regulation of chemokine production

Across TCGA patient cohorts, RNA activity of the Negative regulation of chemokine production pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3BGRL3, LINC01146, and SETP11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine production activity versus SH3BGRL3 in LUAD (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SH3BGRL3 →	+0.429	+0.577	.002	.004	3	4
BRCA	LINC01146 →	+0.146	+0.580	.001	<.001	3	4
PDAC	SETP11 →	-0.235	-0.421	<.001	.003	3	3
CCRCC	SIGLEC5 →	+0.070	+0.689	.009	<.001	2	4
CCRCC	RPL7P52 →	-0.278	-0.684	.006	<.001	3	3
OV	SOSTDC1 →	-1.514	-0.161	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032682 vs SH3BGRL3 — LUAD

Explore this scatter interactively →