Negative regulation of chemokine production

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESN1, ARL6IP1, and NDUFB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SESN1 grouped by Negative regulation of chemokine production-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SESN1 →	+1.039	+0.984	.005	.005	3	5
BLOOD_Leukemia	ARL6IP1 →	+0.698	+1.326	.002	<.001	3	4
STOMACH	NDUFB3 →	-0.639	-1.201	.002	<.001	3	4
STOMACH	BTG2 →	+2.132	+1.228	.003	.008	2	5
OVARY	KRI1 →	-0.804	-1.095	.002	.004	3	4
URINARY_TRACT	TMEM266 →	+0.588	+1.450	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SESN1 by Negative regulation of chemokine production activity — SKIN

Explore this box plot interactively →