Negative regulation of chemokine production

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine production pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS1, LGALS9, and CEACAM1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine production activity versus OAS1 in OESOPHAGUS (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OAS1 →	+3.394	+0.190	<.001	<.001	3	16
STOMACH	LGALS9 →	+3.521	+0.173	<.001	<.001	2	15
PANCREAS	CEACAM1 →	+2.603	+0.172	<.001	<.001	3	11
STOMACH	HSH2D →	+2.823	+0.155	<.001	<.001	3	11
URINARY_TRACT	DZIP1L →	-1.852	-0.131	<.001	<.001	3	11
SKIN	NISCH →	-1.017	-0.117	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032682 vs OAS1 — OESOPHAGUS

Explore this scatter interactively →