Negative regulation of chemokine production

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYBG1, CDS1, and MERTK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine production activity versus CRYBG1 in SKIN (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CRYBG1 →	-2.275	-0.377	<.001	<.001	3	4
BREAST	CDS1 →	-1.522	-1.293	.004	<.001	3	4
SKIN	MERTK →	+2.109	+0.321	<.001	<.001	3	4
LARGE_INTESTINE	ITGB4 →	-1.547	-0.691	.006	.006	3	4
LARGE_INTESTINE	COX11 →	+0.850	+0.875	<.001	.002	3	4
PANCREAS	AFAP1L2 →	-2.123	-0.285	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032682 vs CRYBG1 — SKIN

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