Detection of lipopolysaccharide

Across TCGA patient cohorts, RNA activity of the Detection of lipopolysaccharide pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB1, CSRP2, and LINC01173, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of lipopolysaccharide activity versus SCARB1 in OV (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SCARB1 →	+1.192	+0.134	.003	.001	2	6
GBM	CSRP2 →	+0.982	+0.640	<.001	.006	3	4
CCRCC	LINC01173 →	+1.125	+1.178	<.001	.002	3	4
OV	PTGES3P4 →	+0.272	+0.111	.004	.008	3	3
OV	FAM234B →	+0.695	+0.113	.001	<.001	3	3
UCEC	SIRT5 →	-0.358	-0.273	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032497 vs SCARB1 — OV

Explore this scatter interactively →