Detection of molecule of bacterial origin

Across TCGA patient cohorts, RNA activity of the Detection of molecule of bacterial origin pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUSD6, ZNF491, and LRRC32, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of molecule of bacterial origin activity versus SUSD6 in BRCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SUSD6 →	+0.578	+0.127	<.001	<.001	3	5
CCRCC	ZNF491 →	+0.466	+0.150	.002	.006	3	5
BRCA	LRRC32 →	+0.931	+0.178	<.001	<.001	3	5
BRCA	TBC1D2B →	+0.629	+0.153	<.001	<.001	3	5
CCRCC	LINC02848 →	+0.285	+0.143	.003	.004	3	4
BRCA	ZSCAN16-AS1 →	+0.360	+0.124	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032490 vs SUSD6 — BRCA

Explore this scatter interactively →