Detection of molecule of bacterial origin

Across TCGA cell cohorts, RNA activity of the Detection of molecule of bacterial origin pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSTYK, ZBTB37, and CBFB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DSTYK grouped by Detection of molecule of bacterial origin-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DSTYK →	+0.876	+1.846	.007	<.001	3	4
PANCREAS	ZBTB37 →	+0.641	+0.665	<.001	.004	3	4
BLOOD_Myeloma	CBFB →	+0.998	+1.224	.001	.001	3	3
BLOOD_Myeloma	UIMC1 →	+0.653	+1.300	.009	<.001	3	3
STOMACH	FGD1 →	+1.532	+0.738	.001	.004	3	3
LUNG_NSCLC_LUSC	HUWE1 →	+0.864	+0.330	.002	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DSTYK by Detection of molecule of bacterial origin activity — URINARY_TRACT

Explore this box plot interactively →