Detection of molecule of bacterial origin

Across TCGA cell cohorts, RNA activity of the Detection of molecule of bacterial origin pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERINC1, EGLN1, and MYC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERINC1 grouped by Detection of molecule of bacterial origin-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SERINC1 →	+0.206	+0.225	.006	.005	3	3
SOFT_TISSUE	EGLN1 →	-0.300	-0.255	<.001	<.001	3	3
SOFT_TISSUE	MYC →	+0.284	+0.222	.008	.004	3	3
OESOPHAGUS	CREBBP →	-0.240	-0.228	<.001	.002	3	3
LUNG_SCLC	MARK3 →	-0.172	-1.309	.004	<.001	3	3
BONE	NANOG →	+0.231	+0.329	.003	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERINC1 by Detection of molecule of bacterial origin activity — SOFT_TISSUE

Explore this box plot interactively →