Otolith morphogenesis

Across TCGA cell cohorts, RNA activity of the Otolith morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM8, WDR48, and ARHGEF3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDM8 grouped by Otolith morphogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRDM8 →	+0.191	+1.656	.008	<.001	3	3
SOFT_TISSUE	WDR48 →	-0.399	-1.610	<.001	.001	3	3
BLOOD_Leukemia	ARHGEF3 →	+0.217	+0.946	.002	.005	3	3
SOFT_TISSUE	STAG3L4 →	+0.263	+1.699	.003	<.001	3	3
SOFT_TISSUE	MMD →	-0.248	-1.553	.001	<.001	3	3
SOFT_TISSUE	EPB41 →	-0.321	-1.753	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDM8 by Otolith morphogenesis activity — SOFT_TISSUE

Explore this box plot interactively →