Positive regulation of cytokinesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytokinesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, RACGAP1, and RPL12_S38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytokinesis activity versus TOP2A in LUAD (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A →	+0.997	+0.102	<.001	<.001	3	10
LUAD	RACGAP1 →	+0.730	+0.090	<.001	<.001	3	10
LUAD	RPL12_S38 →	+0.943	+0.080	<.001	<.001	3	9
LUAD	RRM2 →	+0.708	+0.086	<.001	<.001	3	9
GBM	SETDB1_S1066 →	+1.194	+0.126	<.001	.001	3	9
PDAC	BAZ1B_S349 →	+1.000	+0.062	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032467 vs TOP2A — LUAD

Explore this scatter interactively →