Intracellular oxygen homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular oxygen homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STUB1_S19, RSF1, and TLN1_S1225, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular oxygen homeostasis activity versus STUB1_S19 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STUB1_S19 →	+0.551	+0.041	.005	<.001	3	5
HNSC	RSF1 →	+0.235	+0.054	<.001	<.001	3	4
HNSC	TLN1_S1225 →	-0.440	-0.042	.001	.008	3	4
HNSC	NCAPH2 →	+0.310	+0.058	<.001	.005	3	4
OV	EGLN1 →	+0.330	+0.044	.001	<.001	3	4
LUAD	SYNPO_S685 →	-0.239	-0.032	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032364 vs STUB1_S19 — BRCA

Explore this scatter interactively →