GO:0032286Ontology (GO BP)GO biological process · ~5 member genes
Q-omics provides the Central nervous system myelin maintenance (GO:0032286) pathway profile, scoring each patient from the combined activity of its roughly 5 member genes. Pathway activity is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 12, with the highest sampling consensus in BLCA. Additionally, pathway RNA activity shows 30,766 significant cross-omics associations, again with the highest sampling consensus in ESCA. Together, these results highlight COAD, BLCA, and ESCA as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Central nervous system myelin maintenance survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Central nervous system myelin maintenance activity shows favorable associations in MESO, SKCM and THCA, but unfavorable associations in COAD, LUAD and ESCA. In the COAD Kaplan–Meier curve the high-activity group declines faster, consistent with the unfavorable association (log-rank p = .001). COAD ranks highest by sampling consensus for Central nervous system myelin maintenance.
This table summarizes Central nervous system myelin maintenance tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 12 cancer types, while mass-spec protein activity shows differences in 2. The strongest signals are in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across KIRC and lower tumor activity in BLCA, HNSC, KICH, UCEC and LUSC. In the BLCA box plot, normal samples show higher pathway activity than tumor samples (log2 FC = −0.197, t-test p < 0.001).
This table shows molecular features associated with Central nervous system myelin maintenance pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in ESCA. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in BLOOD_Myeloma.
