Central nervous system myelin maintenance

Across TCGA cell cohorts, RNA activity of the Central nervous system myelin maintenance pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPSM1, PIGU, and DDX41, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPSM1 grouped by Central nervous system myelin maintenance-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GPSM1 →	-0.124	-0.146	.008	.003	3	4
BONE	PIGU →	+0.362	+0.169	.007	.005	3	4
STOMACH	DDX41 →	-0.228	-0.238	.002	.002	3	4
UPPER_AERODIGESTIVE_TRACT	CLCA2 →	-0.169	-0.142	.004	.005	3	4
KIDNEY	ABCA10 →	-0.172	-0.119	<.001	.001	3	3
BREAST	LARP4 →	+0.244	+0.231	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPSM1 by Central nervous system myelin maintenance activity — BREAST

Explore this box plot interactively →