Central nervous system myelin maintenance

Across TCGA patient cohorts, RNA activity of the Central nervous system myelin maintenance pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP1B1-AS1, SPTLC1P4, and RPL34P27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system myelin maintenance activity versus CYP1B1-AS1 in PDAC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CYP1B1-AS1 →	+0.362	+0.484	<.001	.005	3	4
HNSC	SPTLC1P4 →	-0.606	-0.515	<.001	.002	3	3
OV	RPL34P27 →	-1.266	-0.479	.009	.008	3	3
LUAD	CILP2 →	+0.655	+0.414	.005	.008	3	3
GBM	TECRP1 →	+0.326	+0.586	.001	.001	3	3
GBM	TMEM250 →	-0.260	-0.593	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032286 vs CYP1B1-AS1 — PDAC

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