Positive regulation of gonadotropin secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of gonadotropin secretion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3, CTIF, and SSC5D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gonadotropin secretion activity versus SORBS3 in CCRCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SORBS3 →	+0.456	+0.148	<.001	<.001	3	7
OV	CTIF →	+0.388	+0.116	<.001	<.001	3	7
CCRCC	SSC5D →	+0.777	+0.122	<.001	.001	3	6
LSCC	TAGLN_S166 →	+0.833	+0.118	<.001	.001	3	6
CCRCC	VCAN →	+0.797	+0.113	.002	.003	3	6
CCRCC	VCL_S726 →	+0.827	+0.147	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032278 vs SORBS3 — CCRCC

Explore this scatter interactively →