Positive regulation of gonadotropin secretion

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of gonadotropin secretion pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and BRCA, show the opposite pattern, with lower activity in tumor tissue.

COAD, KIRC, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	All	IV	+0.147	<.001	11	view →
KIRC	Female	All	+0.128	<.001	11	view →
HNSC	Male	IV	+0.140	<.001	9	view →
STAD	All	II,III,IV	+0.124	<.001	9	view →
READ	All	All	+0.138	<.001	7	view →
UCEC	All	All	−0.073	.001	4	view →
BRCA	All	All	−0.039	.002	4	view →
LUAD	Female	All	−0.071	.003	2	view →
LUSC	All	All	−0.054	.001	2	view →
LIHC	Female	III,IV	−0.095	.041	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0032278–COAD

Open the COAD breakdown →