Positive regulation of gonadotropin secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of gonadotropin secretion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBA, SULF1, and THBS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gonadotropin secretion activity versus INHBA in HNSC (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	INHBA →	+1.721	+0.411	<.001	<.001	3	6
HNSC	SULF1 →	+0.879	+0.266	.001	.008	3	5
LUAD	THBS2 →	+1.322	+0.338	<.001	<.001	3	5
HNSC	INHBA-AS1 →	+0.915	+0.398	<.001	<.001	3	5
HNSC	PRRX1 →	+0.799	+0.356	.001	<.001	3	5
BRCA	COL10A1 →	+1.611	+0.361	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032278 vs INHBA — HNSC

Explore this scatter interactively →