Positive regulation of gonadotropin secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of gonadotropin secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIAPH1, SERPING1, and DLK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DIAPH1 grouped by Positive regulation of gonadotropin secretion-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DIAPH1 →	+0.902	+0.336	.007	.002	3	4
BREAST	SERPING1 →	+1.313	+0.666	.003	.003	3	4
LARGE_INTESTINE	DLK2 →	+0.377	+0.784	.002	.002	3	4
LUNG_NSCLC_LUSC	ZNF488 →	+1.914	+1.474	.003	.004	2	5
CNS	SECISBP2L →	-0.627	-0.798	.001	.008	3	3
CNS	NDUFS2 →	-0.267	-0.698	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DIAPH1 by Positive regulation of gonadotropin secretion activity — BLOOD_Lymphoma

Explore this box plot interactively →