Gonadotropin secretion

Across TCGA patient cohorts, RNA activity of the Gonadotropin secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSRP2, ECM2, and SERPINA5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gonadotropin secretion activity versus CSRP2 in BRCA (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CSRP2 →	+0.485	+0.061	.005	.001	3	7
BRCA	ECM2 →	+0.896	+0.084	<.001	<.001	3	7
BRCA	SERPINA5 →	+0.686	+0.094	<.001	<.001	3	6
BRCA	VCL_S795 →	+0.572	+0.102	<.001	<.001	3	6
BRCA	AGO1 →	+0.205	+0.065	.001	<.001	3	6
UCEC	HMCN1 →	+0.615	+0.102	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032274 vs CSRP2 — BRCA

Explore this scatter interactively →