Gonadotropin secretion

Across TCGA pan-cancer cohorts, RNA activity of the Gonadotropin secretion pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Gonadotropin secretion pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCEC and LUAD, show the opposite pattern, with higher activity associated with better survival.

UCEC, HNSC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.903	0.591	<.001	106	view →
HNSC	OS	Median	IV	0.639	0.771	.001	85	view →
MESO	OS	Tertile	All	0.418	0.679	<.001	60	view →
LGG	DFS	Median	All	0.311	0.503	<.001	30	view →
KIRP	DFS	Quartile	All	0.676	1.000	.001	27	view →
BLCA	DFS	Tertile	III,IV	0.334	0.506	.003	26	view →
CHOL	DFS	Tertile	II,III,IV	0.164	0.614	.009	25	view →
LUAD	DFS	Tertile	III,IV	0.490	0.247	.008	23	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.345	.004	20	view →
THCA	OS	Tertile	II,III,IV	0.321	1.000	.001	20	view →
LAML	DFS	Tertile	All	0.446	0.764	.015	18	view →
LUSC	DFS	Median	IV	0.134	0.827	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0032274–UCEC (OS)

Open the UCEC breakdown →