Secretory granule localization

Across TCGA patient cohorts, RNA activity of the Secretory granule localization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF1A, MAP2, and PELI2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secretory granule localization activity versus KIF1A in OV (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KIF1A →	+1.982	+0.301	<.001	.004	3	8
LSCC	MAP2 →	+1.611	+0.898	<.001	<.001	3	8
LSCC	PELI2 →	+0.736	+0.777	.001	<.001	3	5
LSCC	CREB5 →	+0.716	+0.586	<.001	.009	3	5
LSCC	UCHL1 →	+1.533	+0.748	<.001	<.001	3	5
GBM	TANC2 →	+0.583	+0.507	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032252 vs KIF1A — OV

Explore this scatter interactively →