Activation of protein kinase B activity

Across TCGA patient cohorts, RNA activity of the Activation of protein kinase B activity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERRFI1, PPA1, and TGFB3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of protein kinase B activity activity versus ERRFI1 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ERRFI1 →	+0.774	+0.461	<.001	.001	3	3
BRCA	PPA1 →	-0.357	-0.508	.009	.001	3	3
LUAD	TGFB3 →	+0.389	+0.182	.005	<.001	3	3
LUAD	COL6A1 →	+0.473	+0.154	.004	.003	3	3
LUAD	DIRC3-AS1 →	+0.121	+0.145	.003	.005	3	3
LUAD	CORO7 →	+0.245	+0.204	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032148 vs ERRFI1 — BRCA

Explore this scatter interactively →