Activation of protein kinase B activity

Across TCGA cell cohorts, RNA activity of the Activation of protein kinase B activity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSDME, ELMO2, and TPRN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSDME grouped by Activation of protein kinase B activity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GSDME →	+1.149	+0.753	.001	.003	3	4
CNS	ELMO2 →	+0.526	+1.012	.001	<.001	3	4
BLOOD_Lymphoma	TPRN →	+0.890	+2.285	.005	<.001	3	3
LIVER	CETN3 →	+1.128	+1.263	.001	.002	3	3
LIVER	TENT5B →	+1.597	+1.128	.001	.004	3	3
LIVER	ACOT4 →	-1.321	-1.561	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSDME by Activation of protein kinase B activity activity — CNS

Explore this box plot interactively →