Cardiolipin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Cardiolipin biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARFGAP2, EFS, and GZF1_S613, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin biosynthetic process activity versus ARFGAP2 in BRCA (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARFGAP2 →	+0.211	+0.030	<.001	.001	3	6
BRCA	EFS →	-0.466	-0.033	<.001	.001	3	5
BRCA	GZF1_S613 →	+0.631	+0.033	.001	.001	3	5
COAD	MAVS →	+0.236	+0.037	.001	<.001	3	5
LSCC	MTCH2 →	+0.235	+0.033	<.001	<.001	3	5
LSCC	PTPMT1 →	+0.317	+0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032049 vs ARFGAP2 — BRCA

Explore this scatter interactively →