Cardiolipin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Cardiolipin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASE6, DOCK8, and HCLS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin biosynthetic process activity versus RNASE6 in LSCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNASE6 →	-0.579	-0.088	.001	.006	3	4
LUAD	DOCK8 →	-0.358	-0.106	.003	.002	3	3
LUAD	HCLS1 →	-0.457	-0.142	.002	.001	3	3
LUAD	AP1S2 →	-0.298	-0.096	<.001	.006	3	3
BRCA	EIF3LP3 →	+1.079	+0.249	<.001	.003	3	3
BRCA	BCAT2 →	+0.573	+0.221	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032049 vs RNASE6 — LSCC

Explore this scatter interactively →