Positive regulation of fatty acid beta-oxidation

Across TCGA patient cohorts, RNA activity of the Positive regulation of fatty acid beta-oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM114A1, IRS2, and IRS2_S577, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid beta-oxidation activity versus FAM114A1 in LSCC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAM114A1 →	+0.409	+0.081	<.001	<.001	3	6
LUAD	IRS2 →	+0.507	+0.045	.001	.009	3	6
LSCC	IRS2_S577 →	+1.031	+0.113	<.001	<.001	3	6
LSCC	PLOD3 →	+0.411	+0.070	.001	.002	3	6
LSCC	SERPINH1 →	+0.459	+0.076	<.001	<.001	3	6
LSCC	TWIST1_S68 →	+0.723	+0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032000 vs FAM114A1 — LSCC

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