Cellular response to nutrient

Across TCGA patient cohorts, RNA activity of the Cellular response to nutrient pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFS, SLIT3, and ZNF354C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nutrient activity versus EFS in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EFS →	+0.968	+0.438	<.001	.005	3	4
BRCA	SLIT3 →	+0.931	+0.425	<.001	.003	3	4
BRCA	ZNF354C →	+0.530	+0.465	.004	<.001	3	4
LSCC	C2orf16 →	+0.685	+0.580	<.001	.002	3	4
UCEC	MYC →	+0.902	+0.590	.001	.003	3	4
GBM	ACIN1 →	+0.261	+0.354	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031670 vs EFS — OV

Explore this scatter interactively →