Cellular response to nutrient

Across TCGA cell cohorts, RNA activity of the Cellular response to nutrient pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGSF9, HNRNPAB, and ZNF354A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGSF9 grouped by Cellular response to nutrient-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IGSF9 →	-1.597	-0.250	<.001	<.001	3	4
LIVER	HNRNPAB →	-0.572	-0.232	.002	.003	3	4
SKIN	ZNF354A →	-1.061	-0.204	<.001	<.001	3	4
BLOOD_Myeloma	UBL7 →	-0.833	-0.332	.002	.002	3	4
LUNG_NSCLC_LUAD	RPS24 →	+0.384	+0.123	.006	.008	3	4
LUNG_NSCLC_LUAD	CREM →	+0.906	+0.172	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGSF9 by Cellular response to nutrient activity — PANCREAS

Explore this box plot interactively →