Regulation of myelination

Across TCGA patient cohorts, RNA activity of the Regulation of myelination pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTN-AS1, MKS1, and ZNF20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myelination activity versus TTN-AS1 in BRCA (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTN-AS1 →	-0.168	-0.158	.001	<.001	3	4
GBM	MKS1 →	-0.238	-0.636	.001	.004	3	3
GBM	ZNF20 →	-0.314	-1.055	.002	<.001	3	3
GBM	TIRAP →	-0.421	-0.912	.002	.004	3	3
GBM	HARS1 →	-0.161	-0.746	.007	.007	3	3
BRCA	VPS33B →	-0.355	-0.181	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031641 vs TTN-AS1 — BRCA

Explore this scatter interactively →