Positive regulation of cell killing

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell killing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, HLA-C, and IRF1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell killing activity versus HLA-B in LUNG_SCLC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HLA-B →	+3.719	+0.425	<.001	<.001	3	12
CNS	HLA-C →	+3.638	+0.491	<.001	<.001	3	11
LIVER	IRF1 →	+2.467	+0.430	.007	.001	3	9
LIVER	PSMB8 →	+4.787	+0.429	.008	.001	3	9
LARGE_INTESTINE	TNFAIP3 →	+2.376	+0.463	<.001	<.001	3	8
BONE	EMP1 →	+4.912	+0.703	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031343 vs HLA-B — LUNG_SCLC

Explore this scatter interactively →