Positive regulation of cell killing

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of cell killing pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUSC and LIHC, show the opposite pattern, with lower activity in tumor tissue.

KIRC, HNSC, and UCEC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.046	<.001	12	view →
HNSC	All	All	+0.020	<.001	8	view →
UCEC	All	All	+0.039	<.001	6	view →
BRCA	All	III,IV	+0.035	<.001	6	view →
KIRP	Male	All	+0.027	<.001	6	view →
BLCA	Male	III,IV	+0.047	<.001	5	view →
THCA	Female	II,III,IV	+0.032	.001	4	view →
LUSC	Male	III,IV	−0.064	.007	3	view →
LIHC	All	All	−0.009	.038	3	view →
STAD	Female	All	+0.071	.020	2	view →
CHOL	All	II,III,IV	−0.069	.047	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0031343–KIRC

Open the KIRC breakdown →