Peptide modification

Across TCGA patient cohorts, RNA activity of the Peptide modification pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAM, XIAPP3, and P4HA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide modification activity versus PAM in UCEC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAM →	+0.693	+0.197	<.001	<.001	3	4
UCEC	XIAPP3 →	-0.471	-0.159	.004	.001	3	4
LUAD	P4HA1 →	-0.324	-0.411	.005	<.001	3	3
LUAD	MIS18BP1 →	-0.334	-0.410	.003	.003	3	3
UCEC	KIF20B →	-0.544	-0.217	<.001	<.001	3	3
UCEC	FGFR4 →	-1.245	-0.219	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031179 vs PAM — UCEC

Explore this scatter interactively →