SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the SCF-dependent proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BHLHE41, CBX7, and DNAJB9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process activity versus BHLHE41 in LUAD (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BHLHE41 →	+0.707	+0.209	<.001	<.001	3	4
LUAD	CBX7 →	+0.411	+0.115	.003	.005	3	3
CCRCC	DNAJB9 →	+0.404	+0.251	.006	<.001	3	3
CCRCC	SCAMP2 →	+0.255	+0.262	.003	.003	3	3
CCRCC	CRIM1 →	+0.607	+0.296	.003	<.001	3	3
GBM	CENPK →	-0.681	-0.151	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031146 vs BHLHE41 — LUAD

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