Response to caffeine

Across TCGA cell cohorts, RNA activity of the Response to caffeine pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT-ND4L, HNRNPC, and TIMM44, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to caffeine activity versus MT-ND4L in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MT-ND4L →	-1.085	-1.651	.009	<.001	3	5
LUNG_NSCLC_LUSC	HNRNPC →	+0.729	+1.356	.001	.001	3	5
PANCREAS	TIMM44 →	+1.066	+1.714	<.001	<.001	3	4
PANCREAS	HDDC2 →	+1.238	+1.498	<.001	<.001	3	4
PANCREAS	DDX54 →	+0.993	+1.642	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	DTD2 →	+0.945	+1.231	.006	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031000 vs MT-ND4L — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →